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Type of SACT Drug Examples Risk of Diabetes Hyperglycemia Range of any grade Type of diabetes most likely to develop Targeted therapy mTOR inhibitors Everolimus 41, 42 12 50 T2DM Temsirolimus 42 26 PI3K inhibitors Alpelisib 43 37 T2DM Idelialisib 44 28 30 EGFR inhibitor Osimertinib 45 2 T2DM Panitumumab 46, 47 1 10 Multikinase inhibitor Sunitinib 48 50 0 8 Risk of hypoglycemia Reverses T1 T2DM, but also causes hyperglycemia Pazopanib 50 Tyrosine kinase inhibitor TKI Nilotinib 51 6 T2DM Ponatinib 52 3 ALK Inhibitor Ceritinib 53 49 T2DM FLT3 inhibitor Midostaurin 54, 55 7 20 T2DM Gilteritinib 56 13 Monoclonal antibody Gemtuzumab anti CD33 inpatient use 57 10 T2DM Somatostatin Analogues Octreotide, Lanreotide 58 Up to 30 T2DM, but risk of hypoglycemia Chemotherapy Anti metabolite 5 fluorouracil 59, 60 Up to 10 T2DM Pemetrexed 61, 62 4 Decitadine Azacitidine 63 6 33 Alkylating agents Busulfan 64 66 67 Platinum based Oxaliplatin 65, 66 4 Anthracyclines Doxorubicin 60, 67 Up to 10 Other Arsenic trioxide ATO 68 45 Immune Checkpoint Inhibitors PD 1 Nivolumab 69 T1DM Pembrolizumab 70 1 2 generic cialis cost